Understanding how organs shrink in response to reduced demand
Mechanisms of Physiological Organ Shrinkage
This study looks at why and how organs, especially the intestine, get smaller when they aren't used as much, using fruit flies to learn more about the process, which could help us understand both normal and unhealthy changes in our organs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10912723 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the physiological shrinkage of organs, particularly focusing on the intestine. It explores how organs like the intestine, mammary gland, and skeletal muscle reduce in size when functional demand decreases, leading to a loss of cells. The study utilizes a genetically manipulable invertebrate model, specifically the Drosophila adult midgut, to observe and analyze the cellular behaviors and mechanisms involved in this process. By understanding these mechanisms, the research aims to shed light on both healthy and pathological organ shrinkage.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing conditions related to organ shrinkage or dysfunction, particularly those with gastrointestinal disorders.
Not a fit: Patients with stable organ function and no history of organ shrinkage or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into treating conditions associated with excessive organ shrinkage, such as celiac disease.
How similar studies have performed: While the mechanisms of organ shrinkage are not well understood, the use of Drosophila as a model organism has shown promise in other biological studies, indicating potential for success in this novel approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: O'brien, Lucy Erin — Stanford University
- Study coordinator: O'brien, Lucy Erin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.