Understanding how organs communicate in the body
Integrative approaches to dissection of endocrine communication
This study is looking at how different organs in the body communicate with each other and how this communication changes in adult-onset diabetes, with the hope of finding new proteins that could help improve treatment and understanding of the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10896335 on NIH RePORTER |
What this research studies
This research investigates the complex signaling mechanisms between different organs in the body, particularly focusing on how these interactions are altered in diseases like adult-onset diabetes. By utilizing advanced bioinformatics tools and proteomic analysis, the study aims to identify and validate new endocrine proteins that play a role in inter-organ communication. Patients may benefit from insights gained about how these signaling pathways can influence disease progression and treatment responses. The research employs a combination of data analysis and experimental validation to uncover these relationships.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with adult-onset diabetes or related metabolic disorders.
Not a fit: Patients with isolated endocrine disorders not involving inter-organ communication may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing complex diseases by targeting inter-organ signaling pathways.
How similar studies have performed: Other research has shown promise in understanding inter-organ signaling, but this approach is innovative in its comprehensive bioinformatics framework linking population data to experimental validation.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Seldin, Marcus Michael — University of California-Irvine
- Study coordinator: Seldin, Marcus Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.