Understanding how organelles move and function within cells
Integrative mechanisms of organelle dynamics from the atomic-to-cellular level
This study is exploring how tiny parts of our cells, especially mitochondria, move around and stay in the right places, using a mix of lab experiments and computer models to understand the forces and helpers that make this happen.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10820446 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that control the transport and placement of organelles within cells, focusing on mitochondria as a model system. By combining insights from biophysics and cell biology, the team aims to understand how various molecular components interact to facilitate organelle dynamics. The approach includes studying the native environments of cells and using computational models alongside experimental tests to validate findings. This multi-disciplinary effort seeks to uncover the roles of mechanical forces and regulatory elements in organelle movement.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions linked to mitochondrial dysfunction or other cellular transport disorders.
Not a fit: Patients with conditions unrelated to cellular transport mechanisms or organelle function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cellular function and potential treatments for diseases related to organelle dysfunction.
How similar studies have performed: Other research has shown success in understanding organelle dynamics, but this approach aims to provide a more integrated and comprehensive understanding, making it a novel effort.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Ostap, E. Michael — University of Pennsylvania
- Study coordinator: Ostap, E. Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.