Understanding how organelles change to support healthy aging
Official title: Targeting Mechanisms of Organelle Remodeling to Promote Healthy Aging
Funded at Harvard School of Public Health · NIH-10912777 · Data updated 2026-11-12
This study looks at how tiny parts of our cells called peroxisomes help us age healthily by changing their shape and function when we fast, and it hopes to find ways that this knowledge can help people improve their health as they get older.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard School of Public Health NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $129,465 |
| NIH project number | 5K99AG078343-02 |
| Project ID | NIH-10912777 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in dietary interventions, particularly those exploring fasting or metabolic health.
✕Less likely to help
Patients who are not interested in dietary changes or who have metabolic disorders unrelated to lipid metabolism may not benefit from this research.
What this research studies
This research investigates the role of peroxisomes, which are organelles involved in lipid metabolism, in promoting healthy aging. The study focuses on how these organelles remodel their shape and function during fasting, a state that enhances lipid oxidation. By examining the mechanisms behind this remodeling, the research aims to uncover how it contributes to metabolic flexibility and longevity. Patients may benefit from insights into dietary interventions that could improve health outcomes as they age.
Why it matters
Potential benefit: If successful, this research could lead to new dietary strategies that enhance longevity and metabolic health in aging individuals.
How similar studies have gone: Other research has shown promising results in understanding the role of organelles in metabolism and aging, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Harvard School of Public Health
Boston, United States Active
Researchers
- Principal investigator: Sharma, Arpit — Harvard School of Public Health
- Study coordinator: Sharma, Arpit
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.