Understanding how organelle deficits contribute to Alzheimer's disease
Official title: Intracellular organelle deficits driving Alzheimer's disease
Funded at Rosalind Franklin Univ of Medicine & Sci · NIH-10875741 · Data updated 2026-11-12
This study is looking at how problems with tiny parts inside our brain cells might contribute to Alzheimer's disease, and it hopes to find new ways to help improve brain health for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rosalind Franklin Univ of Medicine & Sci NIH-funded |
| Lab location | 1 site (North Chicago, United States) |
| Project start | September 1, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $431,155 |
| NIH project number | 4R01AG065628-02 |
| Project ID | NIH-10875741 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those exhibiting early signs of cognitive impairment.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the role of intracellular organelles in the progression of Alzheimer's disease (AD). It focuses on how dysfunction in organelles like the endoplasmic reticulum, lysosomes, and mitochondria can lead to the accumulation of harmful proteins and cognitive decline. By using advanced techniques such as 2-photon microscopy, the study aims to explore the interdependence of these organelles and their collective impact on neuronal health. Patients may benefit from insights that could lead to new therapeutic strategies targeting these organelle functions.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that slow down or prevent cognitive decline in Alzheimer's patients.
How similar studies have gone: Previous research has shown promising results in understanding organelle dysfunction in Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Rosalind Franklin Univ of Medicine & Sci
North Chicago, United States Active
Researchers
- Principal investigator: Stutzmann, Grace E. — Rosalind Franklin Univ of Medicine & Sci
- Study coordinator: Stutzmann, Grace E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.