Understanding how oral cancer cells grow and change
Functional exploration of progenitor renewal and differentiation in oral epithelial homeostasis and cancer
This study is looking at how certain changes in cells can lead to head and neck cancers, with the goal of finding better ways to treat patients who have these types of cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10677648 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the growth and transformation of cells in head and neck squamous cell carcinoma (HNSCC), the most common cancer originating from the oral and maxillofacial region. By examining how cancer-associated changes affect the behavior of epithelial cells, the study aims to uncover the balance between cell renewal and differentiation. The researchers will utilize advanced techniques to observe these processes in living organisms, focusing on the role of specific genetic mutations and environmental factors in tumor development. This work seeks to provide insights that could lead to improved treatment strategies for patients with oral cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with head and neck squamous cell carcinoma.
Not a fit: Patients with cancers unrelated to the oral or maxillofacial region may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with head and neck cancers.
How similar studies have performed: Previous research has shown promising results in understanding cancer cell behavior through similar approaches, indicating potential for success in this area.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Ying, Zhe — Icahn School of Medicine at Mount Sinai
- Study coordinator: Ying, Zhe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.