Understanding how oral bacteria can cause infections
Oral Streptococcal Fitness And Virulence genes
This study is looking at how a common mouth bacteria called Streptococcus sanguinis can cause infections like endocarditis, especially during dental work, and aims to find out which genes help it survive in our bodies so we can create better ways to prevent or treat these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-10889010 on NIH RePORTER |
What this research studies
This research investigates the role of the oral bacterium Streptococcus sanguinis in causing infections like endocarditis. It aims to identify specific genes that help this bacterium survive and thrive in the human body, particularly during dental procedures or routine oral activities. By using advanced genomic technologies, the study will analyze how these genes function in different environments, such as saliva and blood, to better understand their impact on health. The findings could lead to the development of new treatments or preventive measures against infections caused by this bacterium.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of dental procedures or those at risk for infective endocarditis.
Not a fit: Patients who do not have any dental issues or are not at risk for infections related to oral bacteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies or preventive strategies for infections linked to oral bacteria.
How similar studies have performed: Other research has shown promise in understanding bacterial genetics and their role in infections, making this approach both relevant and potentially impactful.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Xu, Ping — Virginia Commonwealth University
- Study coordinator: Xu, Ping
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.