Understanding how oral bacteria adapt and transfer genes
Mechanisms of Integrative and Conjugative Elements in Oral Bacteria
['FUNDING_R01'] · ARKANSAS STATE UNIVERSITY · NIH-11167750
This study looks at how a common bacteria in your mouth, called Streptococcus mutans, changes and learns to survive better, which can lead to cavities and make it harder to treat with antibiotics, and it hopes to find ways to help prevent dental problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ARKANSAS STATE UNIVERSITY (nih funded) |
| Locations | 1 site (STATE UNIVERSITY, UNITED STATES) |
| Trial ID | NIH-11167750 on ClinicalTrials.gov |
What this research studies
This research investigates how the oral bacterium Streptococcus mutans adapts to its environment and develops traits that may contribute to dental caries. It focuses on the mechanisms by which this bacterium acquires new DNA from its surroundings, which can enhance its survival and resistance to antibiotics. The study examines mobile genetic elements that facilitate this gene transfer and their role in the bacterium's ability to thrive under various ecological pressures. By understanding these processes, researchers aim to uncover potential targets for preventing dental caries and managing antibiotic resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals of all ages, particularly those at risk for dental caries or with concerns about antibiotic resistance.
Not a fit: Patients who do not have dental issues or are not concerned about antibiotic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing dental caries and combating antibiotic resistance in oral bacteria.
How similar studies have performed: Previous research has shown success in understanding gene transfer mechanisms in bacteria, indicating that this approach has potential for meaningful insights.
Where this research is happening
STATE UNIVERSITY, UNITED STATES
- ARKANSAS STATE UNIVERSITY — STATE UNIVERSITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHIELDS, ROBERT COLQUHOUN — ARKANSAS STATE UNIVERSITY
- Study coordinator: SHIELDS, ROBERT COLQUHOUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.