Understanding how optic glioma causes vision loss
Official title: Defining the Extrinsic and Intrinsic Mechanisms of Vision Loss in Optic Glioma
Funded at Washington University · NIH-10985287 · Data updated 2026-11-12
This study is looking at how optic glioma affects vision loss and aims to find ways to protect and restore eyesight by understanding the factors that harm the eye's nerve cells, using a mouse model to help guide future treatments for people with this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $178,918 |
| NIH project number | 1K08NS133966-01A1 |
| Project ID | NIH-10985287 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and adults diagnosed with neurofibromatosis type 1 who have developed optic pathway glioma.
✕Less likely to help
Patients without optic glioma or those with other unrelated vision loss conditions may not benefit from this research.
What this research studies
This research investigates the mechanisms behind vision loss in patients with optic glioma, particularly focusing on the role of neurodegeneration in the visual system. The project aims to explore both extrinsic factors, such as estrogen, and intrinsic factors, like cyclic-AMP, that contribute to the death of retinal ganglion cells. By using a mouse model of optic pathway glioma, the research seeks to identify potential therapeutic targets for restoring vision. The principal investigator will receive training to enhance their skills in scientific research and clinical practice.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that restore vision in patients affected by optic glioma.
How similar studies have gone: Previous research has shown promise in understanding neurodegeneration in similar contexts, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Tang, Yunshuo Caroline — Washington University
- Study coordinator: Tang, Yunshuo Caroline
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.