Understanding how opioids and cocaine affect brain cells in people with HIV
Single Cell Transcriptomic and Epigenomic Dissection of Opioid and Cocaine Responses in HIV
This study is looking at how opioids and cocaine affect brain cells in people living with HIV, hoping to learn more about how addiction can impact thinking and memory problems related to the virus.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10888187 on NIH RePORTER |
What this research studies
This research investigates the effects of opioids and cocaine on different types of brain cells in individuals living with HIV. By analyzing the genetic and epigenetic changes in these cells, the study aims to uncover how substance use disorder interacts with HIV-related neurological disorders. The approach involves detailed profiling of brain cells to understand their molecular characteristics and how they are altered by addiction. This could lead to insights into the mechanisms behind cognitive impairments associated with HIV and substance use.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who also have a history of opioid or cocaine use.
Not a fit: Patients who do not have HIV or a history of substance use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cognitive impairments in HIV-infected individuals who struggle with substance use disorders.
How similar studies have performed: Previous research has shown promising results in understanding the molecular impacts of addiction on brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
Cambridge, United States
- Broad Institute, INC. — Cambridge, United States (Active)
Researchers
- Principal investigator: Kellis, Manolis — Broad Institute, INC.
- Study coordinator: Kellis, Manolis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.