Understanding how opioids affect brain connections and behavior
Investigating a novel regulatory pathway for opioid-induced synaptic plasticity and behavior
This study is looking at how opioids affect the brain and contribute to addiction, with the goal of finding new ways to help people who struggle with pain and addiction.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa City VA Medical Center NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10946723 on NIH RePORTER |
What this research studies
This research investigates the underlying mechanisms of opioid addiction and relapse, particularly focusing on how opioids alter brain connections in the nucleus accumbens, a key area involved in addiction. By examining the role of specific ion channels and signaling pathways, the study aims to identify new therapeutic targets that could lead to better treatments for pain and addiction. The research utilizes advanced techniques to analyze synaptic changes and behavioral outcomes in response to opioid exposure, providing insights that could help predict addiction risk and improve patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of opioid use or those at risk of developing opioid addiction, particularly veterans.
Not a fit: Patients who are not affected by opioid addiction or do not have a history of opioid use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for individuals struggling with opioid addiction and pain management.
How similar studies have performed: Previous research has shown promise in understanding the mechanisms of addiction through similar approaches, indicating potential for success in this novel investigation.
Where this research is happening
Iowa City, United States
- Iowa City VA Medical Center — Iowa City, United States (Active)
Researchers
- Principal investigator: Wemmie, John a — Iowa City VA Medical Center
- Study coordinator: Wemmie, John a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.