Understanding how opioids affect brain circuits related to addiction
Opioid-induced dysregulation of cortico-striatal circuits
This study is looking at how opioid drugs affect the brain, especially in women, to understand why some people become dependent on them and have trouble thinking clearly, with the goal of finding better ways to help those struggling with opioid addiction.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Marquette University NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11078864 on NIH RePORTER |
What this research studies
This research investigates the neurological effects of opioid drugs on brain circuits that are involved in addiction and cognitive function. It aims to understand how opioids can lead to dependence and cognitive impairments, particularly focusing on individual differences in response to these drugs. The study will explore the role of specific brain regions and circuits, especially in females, to identify factors that contribute to addiction risk or resilience. By examining these mechanisms, the research seeks to provide insights that could inform more effective treatments for opioid addiction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been prescribed opioids for pain management and may be at risk for developing addiction or cognitive impairments.
Not a fit: Patients who have not been exposed to opioids or those with non-addictive pain management strategies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating opioid addiction and its cognitive effects.
How similar studies have performed: Previous research has shown promising results in understanding the neurological basis of addiction, suggesting that this approach could yield valuable insights.
Where this research is happening
Milwaukee, United States
- Marquette University — Milwaukee, United States (Active)
Researchers
- Principal investigator: Hearing, Matthew Carl — Marquette University
- Study coordinator: Hearing, Matthew Carl
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.