Understanding how opioid receptors work at a molecular level
Molecular genetic mechanisms of opioid receptor signaling
This study is looking at how certain genes and molecules affect how opioid receptors work, which is important for treating pain and addiction, using a tiny worm that has been modified to have human opioid receptors, to help find safer ways to use opioids and improve addiction treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11128841 on NIH RePORTER |
What this research studies
This research investigates the genetic and molecular mechanisms that regulate the signaling of opioid receptors, which are crucial for pain management and addiction. By using a special model organism, C. elegans, that has been genetically modified to express human opioid receptors, researchers can observe how these receptors behave and respond to opioids. The study aims to identify new regulators of opioid receptor signaling, which could lead to safer opioid treatments and better management of addiction and withdrawal symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are experiencing pain and may require opioid treatment, as well as those struggling with opioid addiction.
Not a fit: Patients who do not use opioids or are not affected by pain or addiction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of safer opioid medications that minimize the risk of addiction and improve pain management.
How similar studies have performed: Previous research using similar genetic approaches has successfully identified key regulators of opioid receptor signaling, indicating a promising avenue for further exploration.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Grill, Brock — Seattle Children's Hospital
- Study coordinator: Grill, Brock
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.