Understanding how oocytes remain viable during long periods of inactivity
Molecular control of oocyte arrest, meiosis, and the transition to development
['FUNDING_OTHER'] · MARINE BIOLOGICAL LABORATORY · NIH-10897006
This study looks at how human eggs can stay inactive for a long time before they’re ready to develop and be fertilized, especially as women get older, to help improve reproductive health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MARINE BIOLOGICAL LABORATORY (nih funded) |
| Locations | 1 site (WOODS HOLE, UNITED STATES) |
| Trial ID | NIH-10897006 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms that allow human oocytes to remain in a dormant state for extended periods before resuming development. It focuses on how these cells maintain their ability to undergo division and fertilization, particularly as maternal age increases. By studying the ovarian environment and the specific molecular signals involved, the research aims to uncover why oocytes lose their competency over time, which is crucial for improving reproductive health outcomes. The study utilizes advanced biological models to explore these processes in detail.
Who could benefit from this research
Good fit: Ideal candidates for this research are women of reproductive age who may be experiencing fertility issues or are concerned about age-related reproductive challenges.
Not a fit: Patients who are not of reproductive age or those who have undergone procedures that eliminate oocyte viability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing fertility and reducing the risks of genetic disorders in offspring.
How similar studies have performed: While the specific molecular mechanisms of oocyte arrest are still being explored, related research has shown promising results in understanding reproductive biology and improving fertility treatments.
Where this research is happening
WOODS HOLE, UNITED STATES
- MARINE BIOLOGICAL LABORATORY — WOODS HOLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SWARTZ, STEVEN ZACHARY — MARINE BIOLOGICAL LABORATORY
- Study coordinator: SWARTZ, STEVEN ZACHARY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.