Understanding how olfactory receptor genes are regulated in smell neurons
Identifying the mechanism of olfactory receptor gene regulation in olfactory neurons with live-cell imaging
['FUNDING_CAREER'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-11110864
This study is looking at how certain genes that help us smell are controlled in our nose's nerve cells, and it's for anyone interested in understanding how our sense of smell works and how it might be affected by different brain conditions.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11110864 on ClinicalTrials.gov |
What this research studies
This research investigates the regulation of olfactory receptor genes in neurons responsible for our sense of smell. Using advanced live-cell imaging techniques, the study aims to uncover how specific transcription factors interact to control the expression of these genes. By focusing on the mechanisms that allow a single olfactory receptor gene to be expressed in each neuron, the research seeks to provide insights into the fundamental processes of olfactory perception. This could have implications for understanding how olfactory function is affected in various neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing olfactory dysfunction or those with neurodegenerative disorders that may impact their sense of smell.
Not a fit: Patients with intact olfactory function and no neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of olfactory dysfunction, potentially leading to new treatments for conditions that affect the sense of smell.
How similar studies have performed: While the specific approach of using live-cell imaging for olfactory receptor gene regulation is novel, similar studies have shown success in understanding gene expression mechanisms in other contexts.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PULUPA, JOAN M. — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: PULUPA, JOAN M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease