Understanding how Oct4 protein interacts with DNA to regulate gene expression
Configuration-specific cofactors of Oct4
['FUNDING_R03'] · UNIVERSITY OF UTAH · NIH-10713592
This study is looking at how a special protein called Oct4 helps control gene activity during the early stages of embryo development, which could help us understand certain diseases better and improve treatments.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF UTAH (nih funded) |
| Locations | 1 site (SALT LAKE CITY, UNITED STATES) |
| Trial ID | NIH-10713592 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the Oct4 transcription factor in regulating gene expression during early embryonic development and its potential implications for diseases. By examining how Oct4 binds to DNA in different configurations, the study aims to identify specific cofactors that influence transcription output. The researchers will use advanced techniques like affinity purification and mass spectrometry to analyze these interactions, which could enhance our understanding of Oct4's functions and improve reprogramming efficiency for therapeutic purposes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Beckwith-Wiedemann Syndrome or related conditions that may involve Oct4-related gene regulation.
Not a fit: Patients with conditions unrelated to Oct4 function or those not affected by genetic disorders may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for cell reprogramming and differentiation, benefiting patients with genetic disorders linked to Oct4 dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding transcription factors and their cofactors, indicating that this approach could yield valuable insights.
Where this research is happening
SALT LAKE CITY, UNITED STATES
- UNIVERSITY OF UTAH — SALT LAKE CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TANTIN, DEAN — UNIVERSITY OF UTAH
- Study coordinator: TANTIN, DEAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Beckwith-Wiedemann Syndrome, Beckwith syndrome, Exomphalos-Macroglossia-Gigantism Syndrome, Wiedemann syndrome, Wiedemann-Beckwith-Combs syndrome