Understanding how obesity affects the transition from health to cardiometabolic diseases
Multimodal omics approach to identify health to cardiometabolic disease transitions
This study is looking at how obesity affects the body and can lead to conditions like type 2 diabetes and fatty liver disease, and it needs patients to help by providing samples so researchers can find out what causes these health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10905018 on NIH RePORTER |
What this research studies
This research investigates the biological mechanisms that lead to cardiometabolic diseases, such as type 2 diabetes and non-alcoholic fatty liver disease, particularly in the context of obesity. By analyzing fat tissue at both the single-cell and bulk levels, the study aims to identify specific genetic and environmental factors that contribute to these health transitions. The research will utilize advanced techniques like RNA sequencing and ATAC sequencing to uncover how inflammation and insulin resistance in fat cells influence disease development. Patients may be involved in providing biological samples to help identify these critical markers.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with obesity who are at risk for developing cardiometabolic diseases.
Not a fit: Patients who are not affected by obesity or do not have any risk factors for cardiometabolic diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating cardiometabolic diseases in individuals affected by obesity.
How similar studies have performed: Previous research has shown success in using omics approaches to understand disease mechanisms, making this a promising area of investigation.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Pajukanta, Paivi — University of California Los Angeles
- Study coordinator: Pajukanta, Paivi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.