Understanding how obesity affects the lining of the uterus
Official title: Investigating obesity and adiposity-induced alterations to the human endometrium
Funded at University of Michigan at Ann Arbor · NIH-10985393 · Data updated 2026-11-12
This study is looking at how being overweight affects the lining of the uterus, which is important for having regular periods and getting pregnant, to help find better ways to support women facing infertility due to obesity.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $195,000 |
| NIH project number | 1R21HD113812-01A1 |
| Project ID | NIH-10985393 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women over 21 years old who are experiencing infertility issues potentially related to obesity.
✕Less likely to help
Patients who are not affected by obesity or those with infertility due to non-obesity-related factors may not benefit from this research.
What this research studies
This research investigates the impact of obesity on the endometrium, the tissue lining the uterus, which plays a crucial role in reproduction. It aims to explore how obesity-related changes can lead to menstrual irregularities and infertility, particularly focusing on the process of endometrial decidualization, which is essential for successful implantation of an embryo. By examining human primary cells and utilizing mouse models, the study seeks to identify specific alterations in the endometrium caused by obesity. This could help in developing targeted interventions for women struggling with infertility linked to obesity.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for women facing infertility due to obesity.
How similar studies have gone: Previous studies have shown promising results in understanding the relationship between obesity and reproductive health, indicating that this research builds on established findings.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Schon, Samantha Beth — University of Michigan at Ann Arbor
- Study coordinator: Schon, Samantha Beth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.