Understanding how obesity affects liver and kidney metabolism
In vivo hepato-renal metabolic flux dysregulation in obesity
This study is looking at how being overweight affects how your liver and kidneys work, especially in managing sugar and energy in your body, to find better ways to help people with obesity-related health issues.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-11035203 on NIH RePORTER |
What this research studies
This research investigates how obesity alters the metabolic functions of the liver and kidneys, particularly focusing on glucose production and energy metabolism. By using advanced metabolic modeling techniques, the study aims to differentiate the roles of these organs in regulating glucose levels in the body. The research will explore how obesity may lead to increased stress on the kidneys and contribute to metabolic disorders, potentially identifying new treatment strategies to mitigate these effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing obesity-related metabolic issues.
Not a fit: Patients who are not obese or do not have metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for metabolic disorders associated with obesity, such as diabetes and kidney disease.
How similar studies have performed: Previous research has shown promising results in understanding metabolic dysregulation in obesity, but this specific approach of differentiating liver and kidney contributions is novel.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Hasenour, Clinton Michael — Vanderbilt University
- Study coordinator: Hasenour, Clinton Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.