Understanding how obesity affects blood vessel function
Molecular Origins of Phenotypic Changes in the Obese Microvascular Endothelium
This study is looking at how being overweight affects tiny blood vessel cells that help keep your blood vessels healthy, with the goal of understanding how this might lead to heart problems and diabetes.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-10886135 on NIH RePORTER |
What this research studies
This research investigates the impact of obesity on the function of microvascular endothelial cells, which are crucial for maintaining healthy blood vessels. By examining how obesity alters these cells, the study aims to uncover the mechanisms behind endothelial dysfunction, a key factor in cardiovascular diseases. The researchers will utilize advanced techniques to analyze specific molecules involved in this process, focusing on their expression in different endothelial cell populations. This work could lead to a better understanding of how obesity contributes to serious health issues like heart disease and diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are obese and at risk for cardiovascular diseases.
Not a fit: Patients who are not obese or do not have cardiovascular disease risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cardiovascular diseases related to obesity.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown that understanding endothelial dysfunction can lead to significant advancements in treating cardiovascular diseases.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Sellers, Hunter Gage — Augusta University
- Study coordinator: Sellers, Hunter Gage
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.