Understanding how obesity affects blood pressure regulation
Sympathetic-Vascular Dysfunction in Obesity-Related Hypertension
This study is looking at how being overweight can affect blood pressure and whether a vitamin can help make blood vessels less sensitive in people with high blood pressure due to obesity, so we can find better ways to treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-10891602 on NIH RePORTER |
What this research studies
This research investigates the relationship between obesity and hypertension, focusing on how factors like high blood sugar and fat levels can increase blood pressure variability. By using a double-blinded, placebo-controlled approach, the study aims to determine how oxidative stress influences the body's response to sympathetic nerve activity, which regulates blood vessel tone. Patients may receive ascorbic acid to see if it can reduce the heightened sensitivity of blood vessels in obese individuals. The goal is to uncover mechanisms that could lead to better treatments for obesity-related hypertension.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are obese and experiencing hypertension.
Not a fit: Patients who are not obese or do not have hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for managing high blood pressure in obese patients.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of obesity-related hypertension, but this specific approach is innovative and may provide new insights.
Where this research is happening
Kansas City, United States
- University of Kansas Medical Center — Kansas City, United States (Active)
Researchers
- Principal investigator: Holwerda, Seth William — University of Kansas Medical Center
- Study coordinator: Holwerda, Seth William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.