Understanding how O-GlcNAcase is regulated in the body
Official title: Structural insights into the functional regulation of O-GlcNAcase
Funded at University of Wisconsin-Madison · NIH-11060406 · Data updated 2026-11-12
This study is exploring a special enzyme that helps with important processes in our bodies, especially related to cancer, and it's designed to support a promising student from an underrepresented background in learning how to discover new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | February 15, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $58,548 |
| NIH project number | 3R01GM152998-02S1 |
| Project ID | NIH-11060406 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the molecular mechanisms of cancer and those who may benefit from novel drug therapies targeting glycosylation processes.
✕Less likely to help
Patients who are not affected by malignancies or do not have an interest in the underlying biochemical processes may not receive direct benefits from this research.
What this research studies
This research focuses on the enzyme O-GlcNAcase, which plays a crucial role in protein glycosylation, a process that affects many biological functions and diseases, including cancer. The project aims to provide personalized mentoring and training for an underrepresented minority predoctoral student, enhancing their skills in drug discovery and biomedical research. By investigating the structural aspects of O-GlcNAcase, the research seeks to uncover insights that could lead to the development of effective therapies for malignancies. The approach combines hands-on training with advanced research methodologies to foster the next generation of scientists.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating various cancers by targeting the regulation of O-GlcNAcase.
How similar studies have gone: Previous research has shown promising results in targeting glycosylation processes in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Jiang, Jiaoyang — University of Wisconsin-Madison
- Study coordinator: Jiang, Jiaoyang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.