Understanding how O-GlcNAc affects mitochondrial function in Alzheimer's disease
O-GLCNAC HOMEOSTASIS REGULATES MITOCHONDRIAL FUNCTION IN ALZHEIMER'S DISEASE
This study is looking at how a specific chemical change in our cells might affect the energy factories in our cells, called mitochondria, and how this could relate to Alzheimer's disease, with the hope of finding new ways to help improve health for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-10837890 on NIH RePORTER |
What this research studies
This research investigates the role of O-GlcNAcylation, a biochemical modification, in regulating mitochondrial function and its implications for Alzheimer's disease (AD). The study aims to explore how changes in O-GlcNAc levels can impact cellular health and contribute to the progression of AD. By examining the enzymes involved in adding and removing this modification, the research seeks to uncover potential mechanisms that lead to mitochondrial dysfunction in patients with Alzheimer's. The findings could provide insights into new therapeutic targets for improving mitochondrial health in AD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting mitochondrial function.
How similar studies have performed: Other research has shown promising results in understanding mitochondrial dysfunction in Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
Kansas City, United States
- University of Kansas Medical Center — Kansas City, United States (Active)
Researchers
- Principal investigator: Slawson, Chad Eric — University of Kansas Medical Center
- Study coordinator: Slawson, Chad Eric
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.