Understanding how NXF2 affects RNA transport in male reproductive cells
Official title: NXF2-mediated RNA transport in the male germline
Funded at University of Michigan at Ann Arbor · NIH-10901177 · Data updated 2026-11-12
This study is looking at how a protein called NXF2 helps move important RNA in male reproductive cells, which is key for fertility, and by understanding this process in specially modified mice, we hope to learn more about male infertility and find new ways to help.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $42,545 |
| NIH project number | 1F31HD112115-01A1 |
| Project ID | NIH-10901177 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men experiencing infertility or difficulty conceiving.
✕Less likely to help
Patients with infertility due to non-genetic factors may not benefit from this research.
What this research studies
This research investigates the role of the NXF2 protein in transporting RNA within male germ cells, which are crucial for fertility. By studying genetically modified mice, the research aims to uncover how disruptions in NXF2 function can lead to infertility. The approach involves analyzing the molecular mechanisms behind RNA transport and its impact on sperm development. Patients may benefit from insights gained about male infertility and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for male infertility.
How similar studies have gone: Previous research on RNA transport mechanisms in reproductive biology has shown promising results, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Lawson, Ann Marie — University of Michigan at Ann Arbor
- Study coordinator: Lawson, Ann Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.