Understanding how nutrients and signals control cell growth and metabolism
Official title: mTORC1 Regulation by Upstream Stimuli
Funded at Ut Southwestern Medical Center · NIH-11092166 · Data updated 2026-11-12
This study is looking at how certain signals in the body affect a protein complex called mTORC1, which is important for cell growth and metabolism, to find new ways to help manage conditions like type 2 diabetes and some cancers, so patients can have better treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $492,000 |
| NIH project number | 5R35GM149351-03 |
| Project ID | NIH-11092166 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with type 2 diabetes, metabolic disorders, or certain cancers.
✕Less likely to help
Patients with conditions unrelated to mTORC1 regulation or those not affected by metabolic disorders may not benefit from this research.
What this research studies
This research investigates how the mTORC1 protein complex, which plays a key role in regulating cell growth and metabolism, is influenced by various upstream signals, particularly amino acids and G-protein coupled receptors. By exploring these regulatory mechanisms, the research aims to identify new therapeutic targets that could help manage diseases associated with elevated mTORC1 activity, such as type 2 diabetes and certain cancers. Patients may benefit from insights gained that could lead to improved treatments for these conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for managing diseases like type 2 diabetes and cancer by targeting the mTORC1 pathway.
How similar studies have gone: Previous research has shown that targeting the mTORC1 pathway can be effective in treating certain diseases, indicating that this approach has potential for success.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Jewell, Jenna L — Ut Southwestern Medical Center
- Study coordinator: Jewell, Jenna L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.