Understanding how nutrients and signals control cell growth and metabolism
mTORC1 Regulation by Upstream Stimuli
This study is looking at how certain signals in the body affect a protein complex called mTORC1, which is important for cell growth and metabolism, to find new ways to help treat conditions like type 2 diabetes and some cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11052570 on NIH RePORTER |
What this research studies
This research investigates how the mTORC1 protein complex, which plays a key role in regulating cell growth and metabolism, is influenced by various upstream signals, particularly amino acids and G-protein coupled receptors. By exploring these regulatory mechanisms, the research aims to identify new therapeutic targets that could help manage diseases associated with elevated mTORC1 activity, such as type 2 diabetes and certain cancers. Patients may benefit from insights that could lead to improved treatments for these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with adult-onset diabetes or related metabolic disorders.
Not a fit: Patients with conditions unrelated to mTORC1 regulation or those not diagnosed with metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better manage or treat conditions like type 2 diabetes and cancer.
How similar studies have performed: Previous research has shown that targeting mTORC1 can be effective in treating certain diseases, indicating a promising avenue for further exploration.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Jewell, Jenna L — Ut Southwestern Medical Center
- Study coordinator: Jewell, Jenna L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.