Understanding how nutrient signals affect breast cancer growth
Nutrient Sensing and Transcriptional Regulation
This study is looking at how Triple Negative Breast Cancer cells grow and survive by responding to nutrients, with the hope of finding new ways to treat this aggressive type of cancer for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10421294 on NIH RePORTER |
What this research studies
This research investigates the molecular pathways that contribute to the growth and survival of Triple Negative Breast Cancer (TNBC), a subtype of breast cancer that is particularly aggressive and lacks targeted therapies. The study focuses on how cancer cells respond to nutrient signals and how these signals influence gene expression, particularly through the action of specific transcription factors like MondoA. By examining these mechanisms, the research aims to identify new therapeutic targets that could lead to more effective treatments for TNBC patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Triple Negative Breast Cancer, particularly those who are younger and facing aggressive disease progression.
Not a fit: Patients with other subtypes of breast cancer or those who do not have breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for Triple Negative Breast Cancer, improving survival rates and treatment options for patients.
How similar studies have performed: Other research has shown promise in targeting metabolic pathways in cancer treatment, suggesting that this approach could yield significant advancements in therapy for TNBC.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Ayer, Donald E — University of Utah
- Study coordinator: Ayer, Donald E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.