Understanding how NUDT5 affects ovarian cancer progression
Official title: Defining the role of NUDT5 in ovarian cancer
Funded at University of California Los Angeles · NIH-10998986 · Data updated 2026-11-12
This study is looking at a protein called NUDT5 to see how it affects the movement of ovarian cancer cells, and researchers are testing different compounds to find new ways to help treat ovarian cancer, especially for those who have trouble with current treatments.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | August 16, 2024 |
| Project end | August 15, 2027 |
| Funding year | 2024 |
| Award (this year) | $45,643 |
| NIH project number | 1F31CA288105-01A1 |
| Project ID | NIH-10998986 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with ovarian cancer, particularly those who have experienced chemotherapy resistance.
✕Less likely to help
Patients with early-stage ovarian cancer who have not undergone treatment may not benefit from this research.
What this research studies
This research investigates the role of NUDT5, a protein that may influence how ovarian cancer cells deform and migrate. By using a high throughput screening method, researchers are testing various compounds to see how they affect the mechanical properties of ovarian cancer cells. The goal is to identify new drug targets that could lead to more effective treatments for patients suffering from ovarian cancer, particularly those facing challenges like chemotherapy resistance and metastasis.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies that improve survival rates for ovarian cancer patients.
How similar studies have gone: Previous research has shown promise in targeting mechanical regulators in cancer, suggesting that this approach could yield significant advancements in treatment.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Flores, Angelina Marybelle — University of California Los Angeles
- Study coordinator: Flores, Angelina Marybelle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.