Understanding how NUDT16 affects DNA damage and cancer development
The role of NUDT16 in DNA damage response and tumorigenesis
This study is looking at a protein called NUDT16 to see how it helps our bodies fix DNA damage, which is important for preventing cancer, and it’s for anyone interested in understanding more about how our cells stay healthy and how we might find new ways to treat cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10977988 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called NUDT16 in the body's response to DNA damage, which is crucial for preventing cancer. The researchers will explore how NUDT16 helps maintain genomic stability by regulating various proteins involved in DNA repair. They will use both laboratory experiments and animal models to understand the physiological functions of NUDT16 and its impact on cancer development. By identifying the mechanisms through which NUDT16 operates, this research aims to uncover new insights into cancer biology and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of cancer or those with genetic predispositions to DNA repair deficiencies.
Not a fit: Patients with cancers unrelated to DNA damage response or those without genetic predispositions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for cancer prevention and treatment by enhancing our understanding of DNA repair mechanisms.
How similar studies have performed: Previous research has shown success in understanding DNA damage response mechanisms, making this approach promising yet still exploring new aspects of NUDT16's role.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Gong, Zihua — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Gong, Zihua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.