Understanding how nucleosomes influence gene regulation
Biophysical Determinants of the Nucleosome as an Activity Center for Chromatin Regulators
This study is looking at how tiny structures in our DNA called nucleosomes help control which genes are turned on or off, and it's for anyone interested in understanding more about how our genes work and how they might be affected in different conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10933394 on NIH RePORTER |
What this research studies
This research investigates the role of nucleosomes, the fundamental units of chromatin, in regulating gene expression. By examining the physical characteristics and arrangement of nucleosomes, the study aims to uncover how these structures interact with chromatin regulators to influence genomic functions. Using advanced techniques like single-molecule fluorescence detection and force manipulation, researchers will track real-time interactions at the molecular level. This approach could reveal new insights into the mechanisms of gene regulation and chromatin architecture.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or diseases that involve chromatin regulation and gene expression.
Not a fit: Patients with conditions unrelated to chromatin structure or gene regulation may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating gene expression, which may benefit patients with genetic disorders or diseases related to chromatin dysfunction.
How similar studies have performed: Other research has shown promising results in understanding chromatin dynamics and gene regulation, indicating that this approach has potential for significant discoveries.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Liu, Shixin — Rockefeller University
- Study coordinator: Liu, Shixin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.