Understanding how nucleosomes influence gene regulation
Official title: Biophysical Determinants of the Nucleosome as an Activity Center for Chromatin Regulators
Funded at Rockefeller University · NIH-10933394 · Data updated 2026-11-12
This study is looking at how tiny structures in our DNA called nucleosomes help control which genes are turned on or off, and it's for anyone interested in understanding more about how our genes work and how they might be affected in different conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 22, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $339,000 |
| NIH project number | 5R01GM149862-02 |
| Project ID | NIH-10933394 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic conditions or diseases that involve chromatin regulation and gene expression.
✕Less likely to help
Patients with conditions unrelated to chromatin structure or gene regulation may not receive any benefit from this research.
What this research studies
This research investigates the role of nucleosomes, the fundamental units of chromatin, in regulating gene expression. By examining the physical characteristics and arrangement of nucleosomes, the study aims to uncover how these structures interact with chromatin regulators to influence genomic functions. Using advanced techniques like single-molecule fluorescence detection and force manipulation, researchers will track real-time interactions at the molecular level. This approach could reveal new insights into the mechanisms of gene regulation and chromatin architecture.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating gene expression, which may benefit patients with genetic disorders or diseases related to chromatin dysfunction.
How similar studies have gone: Other research has shown promising results in understanding chromatin dynamics and gene regulation, indicating that this approach has potential for significant discoveries.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Liu, Shixin — Rockefeller University
- Study coordinator: Liu, Shixin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.