Understanding how nucleolin interacts with a specific DNA structure to regulate cancer genes
Nucleolin recognition of MYC promoter G-quadruplex and its role in MYC regulation by MycG4-ligands
['FUNDING_U01'] · PURDUE UNIVERSITY · NIH-10817725
This study is looking at how a protein called nucleolin interacts with a special DNA structure linked to the c-Myc gene, which plays a role in many cancers, to find new ways to help develop treatments that could improve cancer care for patients.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PURDUE UNIVERSITY (nih funded) |
| Locations | 1 site (WEST LAFAYETTE, UNITED STATES) |
| Trial ID | NIH-10817725 on ClinicalTrials.gov |
What this research studies
This research investigates the interaction between nucleolin, a protein, and a unique DNA structure known as G-quadruplex found in the promoter region of the c-Myc gene, which is crucial in many cancers. The study aims to understand how nucleolin binds to this DNA structure and how small molecules can influence this interaction to regulate c-Myc gene expression. By determining the molecular structure of the nucleolin-G-quadruplex complex, the research seeks to uncover potential new strategies for cancer treatment targeting this mechanism. Patients may benefit from insights that could lead to the development of novel anti-cancer therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers where c-Myc plays a significant role in tumor growth and progression.
Not a fit: Patients with cancers not driven by c-Myc or those with non-malignant conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for cancer by manipulating the regulation of the c-Myc gene.
How similar studies have performed: While the specific approach of targeting the nucleolin-MycG4 complex is novel, similar strategies targeting oncogene regulation have shown promise in other studies.
Where this research is happening
WEST LAFAYETTE, UNITED STATES
- PURDUE UNIVERSITY — WEST LAFAYETTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, DANZHOU — PURDUE UNIVERSITY
- Study coordinator: YANG, DANZHOU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anti-Cancer Agents, Cancer Drug, Neoplastic Disease Chemotherapeutic Agents, anti-cancer drug