Understanding how nucleic acids regulate a key protein involved in cancer development
Regulation of a chromatin modifier (Polycomb Repressive Complex 2) by nucleic acids interactions
['FUNDING_OTHER'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-10670999
This study is looking at how a special protein complex called PRC2 interacts with DNA and RNA to help control gene activity, especially in cancer, with the hope of finding new ways to improve cancer treatments for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10670999 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the Polycomb Repressive Complex 2 (PRC2), a protein complex that modifies chromatin and is crucial for gene regulation during development. The study focuses on how interactions between PRC2 and nucleic acids, such as RNA and DNA, influence its activity and function, particularly in the context of cancer. By exploring these interactions, the research aims to uncover new mechanisms that could lead to innovative therapeutic strategies for cancer treatment. Patients may benefit from insights gained about how to target PRC2 more effectively in cancer therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers where PRC2 is known to be upregulated or mutated.
Not a fit: Patients with cancers not associated with PRC2 dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that more effectively target cancer by manipulating PRC2 activity.
How similar studies have performed: Previous research has shown promising results in targeting chromatin modifiers in cancer, indicating that this approach has potential for success.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LONG, YICHENG — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: LONG, YICHENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer