Understanding how nuclear surveillance is impaired in ALS and FTD
Official title: Mechanisms of impaired ESCRT-III nuclear surveillance in ALS/FTD
Funded at Johns Hopkins University · NIH-11125892 · Data updated 2026-11-12
This study is looking at how certain problems in brain cells might contribute to ALS and Frontotemporal Dementia, focusing on a specific protein called CHMP7, to help find new ways to treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $578,963 |
| NIH project number | 5R01NS132836-03 |
| Project ID | NIH-11125892 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with ALS or FTD, particularly those experiencing early symptoms.
✕Less likely to help
Patients with neurodegenerative diseases unrelated to ALS or FTD may not benefit from this research.
What this research studies
This research investigates the mechanisms behind the impairment of nuclear surveillance in patients with Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). By utilizing induced pluripotent stem cell-derived neurons and human brain tissues, the study aims to uncover how disruptions in the nuclear pore complex affect cellular processes critical for neuronal health. The research focuses on the role of a specific protein, CHMP7, in these neurodegenerative diseases, which may lead to better understanding and potential therapeutic targets for ALS and FTD.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for patients suffering from ALS and FTD.
How similar studies have gone: Previous research has shown promising results in understanding neurodegenerative mechanisms, making this approach both relevant and potentially impactful.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Coyne, Alyssa — Johns Hopkins University
- Study coordinator: Coyne, Alyssa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.