Understanding how nuclear pore components affect blood vessel health.
Official title: Identifying the role of nuclear pore components in vascular function.
Funded at University of Illinois at Chicago · NIH-11047979 · Data updated 2026-11-12
This study is looking at how a specific protein called Nup93 helps keep blood vessels healthy by supporting the cells that line them, and it aims to understand how changes in blood flow can affect these cells to help prevent issues like atherosclerosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | January 1, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $706,220 |
| NIH project number | 1R01HL164406-01A1 |
| Project ID | NIH-11047979 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for atherosclerosis or those with existing cardiovascular conditions.
✕Less likely to help
Patients without cardiovascular risk factors or existing conditions related to vascular health may not benefit from this research.
What this research studies
This research investigates the role of nuclear pore components, specifically Nup93, in maintaining the health of blood vessels by regulating endothelial cells. Endothelial cells are crucial for vascular function as they respond to blood flow and environmental changes. The study aims to uncover how mechanical forces influence gene expression in these cells, particularly focusing on how Nup93 phosphorylation can prevent inflammation and promote a healthy vascular environment. By exploring these mechanisms, the research seeks to provide insights into preventing conditions like atherosclerosis.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating atherosclerosis and other cardiovascular diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of endothelial cell signaling in vascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Lee, Monica Y — University of Illinois at Chicago
- Study coordinator: Lee, Monica Y
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.