Understanding how nuclear pore complexes are affected in ALS and FTD
Mechanisms of nuclear pore complex homeostasis and injury in ALS/FTD and related neurodegenerative diseases
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-10872258
This study is looking at how tiny structures in our cells, called nuclear pore complexes, might be involved in the development of ALS and Frontotemporal Dementia, with the hope of finding new ways to understand and treat these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10872258 on ClinicalTrials.gov |
What this research studies
This research investigates the role of nuclear pore complexes (NPCs) in the development of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). It aims to uncover the molecular mechanisms that lead to the dysfunction of these complexes, which are crucial for cellular transport and communication. By studying both familial and sporadic cases of ALS, the research utilizes advanced imaging techniques to observe changes in NPCs and their components in patient-derived neurons. The findings could provide insights into the underlying causes of these neurodegenerative diseases and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with ALS or FTD, particularly those with sporadic forms of these diseases.
Not a fit: Patients with neurodegenerative diseases unrelated to ALS or FTD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating ALS and FTD by targeting the mechanisms that disrupt nuclear pore function.
How similar studies have performed: Previous research has shown promising results in understanding the role of nuclear pore complexes in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COYNE, ALYSSA — JOHNS HOPKINS UNIVERSITY
- Study coordinator: COYNE, ALYSSA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Amyotrophic Lateral Sclerosis Motor Neuron Disease