Understanding how NT5c1A antibodies affect muscle disease in older adults
Official title: Influence of NT5c1A antibodies on disease progression, clinical phenotype and blood and muscle biomarkers in sporadic Inclusion Body Myositis - A prospective evaluation
Funded at University of California-Irvine · NIH-11081760 · Data updated 2026-11-12
This study is looking at how a specific antibody might affect the progression of sporadic inclusion body myositis (sIBM) in older adults, by tracking changes in muscle and blood over two years to help us better understand the disease and improve future treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | April 1, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $359,826 |
| NIH project number | 5R01AR078340-05 |
| Project ID | NIH-11081760 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who have been diagnosed with sporadic inclusion body myositis.
✕Less likely to help
Patients under the age of 65 or those without a diagnosis of sporadic inclusion body myositis may not benefit from this research.
What this research studies
This research investigates sporadic inclusion body myositis (sIBM), a rare muscle disorder primarily affecting older adults. The study aims to explore the role of NT5c1A antibodies in disease progression and how they relate to muscle and blood biomarkers. By observing patients over a two-year period, researchers will analyze muscle biopsies and blood samples to gain insights into the disease's natural history and its impact on muscle function. This observational approach is designed to fill gaps in knowledge that hinder clinical trials for sIBM.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of sIBM and pave the way for future treatments.
How similar studies have gone: While sporadic inclusion body myositis is a poorly understood condition, similar observational studies have been successful in other rare diseases, suggesting potential for valuable insights here.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Mozaffar, Tahseen — University of California-Irvine
- Study coordinator: Mozaffar, Tahseen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.