Understanding how NSUN2 affects stem cell behavior
Official title: Decoding NSUN2-mediated translational control of pluripotent stem cells
Funded at Columbia University Health Sciences · NIH-10995823 · Data updated 2026-11-12
This study is looking at how a protein called NSUN2 helps keep stem cells in their early, undifferentiated state, which could lead to new ways to use stem cells for treating different health issues, including some developmental disorders and cancers.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 23, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $205,625 |
| NIH project number | 1R21HD116446-01 |
| Project ID | NIH-10995823 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with developmental disorders linked to NSUN2 mutations, such as intellectual disabilities or certain cancers.
✕Less likely to help
Patients with conditions unrelated to NSUN2 or those who do not have developmental disorders may not receive direct benefits from this research.
What this research studies
This research investigates the role of NSUN2, an RNA methyl-transferase, in regulating the translation processes of pluripotent stem cells. By examining how NSUN2 influences the stability and activity of tRNAs and mRNAs, the study aims to uncover mechanisms that maintain stem cells in their undifferentiated state. The research utilizes advanced biological models to explore the effects of NSUN2 mutations, which are linked to various developmental disorders and cancers. Patients may benefit from insights gained into how stem cells can be manipulated for therapeutic purposes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating developmental disorders and cancers by enhancing our understanding of stem cell regulation.
How similar studies have gone: Previous research has shown promising results in understanding the role of RNA methylation in cellular processes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Wang, Jianlong — Columbia University Health Sciences
- Study coordinator: Wang, Jianlong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.