Understanding how NRF2 affects lung squamous cell carcinoma development

Who could benefit from this research

What this research studies

This research investigates the role of the NRF2 transcription factor in lung squamous cell carcinoma (LUSC), which is a type of lung cancer. The study uses a genetically-engineered mouse model to explore how mutations in NRF2 contribute to cancer initiation and progression, as well as how they affect the tumor microenvironment. By examining the gene expression and metabolism changes driven by NRF2, the research aims to uncover mechanisms that lead to poor patient outcomes and resistance to existing therapies. This could provide insights into new treatment strategies for patients with LUSC.

Why it matters

Where this research is happening

• Univ of North Carolina Chapel Hill
  Chapel Hill, United States Active

Researchers

• Principal investigator: Weissman, Bernard E. — Univ of North Carolina Chapel Hill
• Study coordinator: Weissman, Bernard E.

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.