Understanding how NRF2 affects head and neck cancer
Mechanisms Determining Dysregulation of the NRF2 Oxidative Stress Response in Head and Neck Squamous Cell Carcinoma
['FUNDING_CAREER'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10917062
This study is looking at how a protein called NRF2 affects the growth of head and neck cancers and how it might change the way these cancers respond to treatment, with the hope of finding better ways to help patients.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10917062 on ClinicalTrials.gov |
What this research studies
This research investigates the role of NRF2, a key regulator of the oxidative stress response, in head and neck squamous cell carcinoma (HNSCC). The principal investigator, Dr. Travis Schrank, is exploring how mutations and variants in NRF2 and related proteins influence cancer progression and treatment responses. By analyzing RNA-based methods, the research aims to identify tumors with aberrant NRF2 activation and understand the implications of these findings for patient outcomes. The study also examines the potential role of the prohormone Neurotensin in activating NRF2 in tumors without mutations, which could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with head and neck squamous cell carcinoma, particularly those with HPV-negative tumors.
Not a fit: Patients with other types of cancers or those with HPV-positive head and neck tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with head and neck cancer by targeting the NRF2 pathway.
How similar studies have performed: Previous research has shown promising results in targeting oxidative stress responses in cancer, suggesting that this approach may yield significant insights.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHRANK, TRAVIS P. — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: SCHRANK, TRAVIS P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.