Understanding how Nrf2 affects chronic kidney disease
The Role of Nrf2 in Proteinuric Chronic Kidney Disease
['FUNDING_OTHER'] · VETERANS HEALTH ADMINISTRATION · NIH-11109569
This study is looking at a protein called Nrf2 to see how it can help protect kidney cells in people with chronic kidney disease (CKD), especially veterans, and hopes to find new ways to improve treatments for conditions like diabetic nephropathy or Alport syndrome.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VETERANS HEALTH ADMINISTRATION (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11109569 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called Nrf2 in chronic kidney disease (CKD), which affects millions of Americans, particularly veterans. The study aims to explore how Nrf2 can be activated to protect kidney cells from damage and potentially improve treatments for CKD, which is often characterized by proteinuria, or excess protein in urine. By examining the biological mechanisms behind CKD, the research seeks to identify new therapeutic strategies that could slow disease progression or even lead to a cure. Patients may benefit from insights gained through this research, especially those with conditions like diabetic nephropathy or Alport syndrome.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with chronic kidney disease, particularly those experiencing proteinuria.
Not a fit: Patients with non-proteinuric forms of kidney disease or those without chronic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for chronic kidney disease, potentially reducing the need for dialysis or transplantation.
How similar studies have performed: Previous clinical trials using Nrf2 activators like bardoxolone methyl have shown promise in treating proteinuric chronic kidney disease.
Where this research is happening
PITTSBURGH, UNITED STATES
- VETERANS HEALTH ADMINISTRATION — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TAN, RODERICK JASON — VETERANS HEALTH ADMINISTRATION
- Study coordinator: TAN, RODERICK JASON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.