Understanding how NRF2 affects breast cancer spread and recurrence
NRF2 suppression of inflammatory signaling and its role in tumor progression
This work explores how a protein called NRF2 helps breast cancer cells spread and come back, aiming to find new ways to stop it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11132996 on NIH RePORTER |
What this research studies
Many deaths from breast cancer happen when the disease spreads to other parts of the body or returns after treatment. Our team is looking into how cancer cells survive and grow in new locations. We are focusing on a protein called NRF2, which seems to help cancer cells resist stress from treatments and grow back. By understanding NRF2's role in how breast cancer spreads and recurs, we hope to develop better treatments.
Who could benefit from this research
Good fit: This foundational work is relevant to patients with breast cancer, particularly those at risk for metastasis or recurrence.
Not a fit: Patients without breast cancer or those whose cancer does not involve the NRF2 pathway may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new therapies that prevent breast cancer from spreading or recurring, improving outcomes for patients.
How similar studies have performed: Previous findings have identified NRF2's role in local tumor recurrence, suggesting this approach builds on existing knowledge while exploring its role in metastasis.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Alvarez, James V — Fred Hutchinson Cancer Center
- Study coordinator: Alvarez, James V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.