Understanding how NRF2 activation affects cilia in airway diseases
Official title: NRF2 activation program in normal and immotile cilia
Funded at Washington University · NIH-11118689 · Data updated 2026-11-12
This study is looking at how a specific pathway in our cells affects tiny hair-like structures that help keep our lungs healthy, and it's specifically for people with primary ciliary dyskinesia (PCD), a condition that makes these structures not work properly; the researchers want to find out how genes in these cells are different in PCD patients compared to healthy people to discover new ways to help improve treatments for lung problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | June 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $635,451 |
| NIH project number | 5R01HL173490-02 |
| Project ID | NIH-11118689 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with primary ciliary dyskinesia or related airway diseases.
✕Less likely to help
Patients without airway diseases or those not affected by ciliary dysfunction may not benefit from this research.
What this research studies
This research investigates the role of the NRF2 pathway in the function of motile cilia, which are crucial for lung defense. It focuses on patients with primary ciliary dyskinesia (PCD), a genetic condition that leads to impaired cilia function and respiratory issues. By utilizing advanced techniques like single-cell RNA sequencing, the study aims to identify specific gene expression changes in ciliated cells from PCD patients compared to healthy individuals. The goal is to uncover potential therapeutic targets that could improve treatment options for those affected by airway diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for patients with primary ciliary dyskinesia and other airway diseases.
How similar studies have gone: Previous research has shown promise in targeting the NRF2 pathway for various cellular stress responses, indicating potential for success in this novel application.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Horani, Amjad — Washington University
- Study coordinator: Horani, Amjad
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.