Understanding how NRAS signaling affects blood cell cancers
Novel Regulation of Oncogenic NRAS Signaling in Myeloid Malignancies
This study is looking at how certain proteins affect blood cell formation and could help find new treatments for conditions like acute myeloid leukemia, so patients can have better options for their care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11055343 on NIH RePORTER |
What this research studies
This research investigates the regulation of signaling pathways in hematopoietic stem and progenitor cells, which are crucial for blood cell formation. The study focuses on how specific proteins, particularly RAB27B, influence the activity of NRAS, a protein involved in cell growth and cancer development. By exploring the mechanisms that lead to abnormal signaling in myeloid malignancies, the research aims to identify potential therapeutic targets. Patients may benefit from insights that could lead to new treatments for acute myeloid leukemia and related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with acute myeloid leukemia or related blood cancers.
Not a fit: Patients with non-malignant blood disorders or those not diagnosed with myeloid malignancies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for patients with acute myeloid leukemia and improve treatment outcomes.
How similar studies have performed: Previous research has shown promising results in targeting similar signaling pathways in blood cancers, indicating potential for success in this approach.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Tong, Wei — Children's Hosp of Philadelphia
- Study coordinator: Tong, Wei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.