Understanding how NRAS gene changes affect cancer growth
Molecular mechanisms of allele-specific NRAS signaling and tumorigenesis
This research aims to understand how different changes in the NRAS gene lead to various types of cancer, like melanoma and acute myeloid leukemia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11121044 on NIH RePORTER |
What this research studies
We know that changes in the NRAS gene can cause cancer, but not all changes act the same way. This project explores how specific changes in the NRAS gene affect its structure and how it signals within cells, which can influence how a tumor grows. By studying these differences, we hope to learn why certain NRAS changes are more common in some cancers and why they might respond differently to treatments. Our work uses models to observe how these specific NRAS changes lead to cancer development.
Who could benefit from this research
Good fit: Patients with cancers like melanoma, acute myeloid leukemia, or thyroid cancer that are known to have specific NRAS gene mutations could potentially benefit from future treatments developed from this research.
Not a fit: Patients whose cancer is not linked to NRAS gene mutations or similar genetic pathways may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this research could lead to a deeper understanding of NRAS-driven cancers, potentially guiding the development of more effective and personalized treatments for patients.
How similar studies have performed: While other RAS gene mutations like KRAS have been extensively studied, the specific functions of different NRAS mutations are less understood, making this a novel area of focus.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Burd, Christin E — Ohio State University
- Study coordinator: Burd, Christin E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.