Understanding how NR2F6 affects immune cells involved in inflammation
Official title: Defining the Transcriptional Activity of NR2F6 in TH17 cells
Funded at University of Florida · NIH-11044038 · Data updated 2026-11-12
This study is looking at how a protein called NR2F6 affects certain immune cells that can cause problems like inflammatory bowel disease (IBD) when they’re not working right, with the goal of finding new ways to help people with IBD feel better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $35,974 |
| NIH project number | 5F31DK137613-02 |
| Project ID | NIH-11044038 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease or other autoimmune disorders characterized by TH17 cell dysregulation.
✕Less likely to help
Patients without autoimmune conditions or those not affected by inflammatory bowel disease may not benefit from this research.
What this research studies
This research investigates the role of NR2F6, a transcription factor, in regulating TH17 cells, which are crucial for immune responses but can contribute to autoimmune diseases like inflammatory bowel disease (IBD) when dysregulated. By examining how NR2F6 influences the production of pro-inflammatory cytokines, the research aims to identify new therapeutic targets that could improve treatment outcomes for patients with IBD. The approach involves genetic experiments and advanced sequencing techniques to analyze the transcriptional activity of NR2F6 in TH17 cells. This could lead to a better understanding of the mechanisms behind chronic inflammation and autoimmunity.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that more effectively manage inflammatory bowel disease and other autoimmune conditions.
How similar studies have gone: Previous research has shown promise in targeting transcription factors like NR2F6 for therapeutic interventions in autoimmune diseases, indicating a potential for success in this approach.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Wilson, Adrianna Nicole — University of Florida
- Study coordinator: Wilson, Adrianna Nicole
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.