Understanding how NPM1c mutations affect leukemia
Defining epigenetic mechanisms in NPM1c mutant leukemia
['FUNDING_R01'] · DANA-FARBER CANCER INST · NIH-11056773
This study is looking at how changes in a gene called NPM1 affect acute myeloid leukemia (AML) and how these changes help cancer cells survive, with the goal of finding new treatment options for patients like you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DANA-FARBER CANCER INST (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11056773 on ClinicalTrials.gov |
What this research studies
This research investigates the role of NPM1 mutations in acute myeloid leukemia (AML) and how these mutations lead to abnormal gene expression patterns that promote cancer cell survival. The team will explore the interaction between specific proteins, Menin and MLL, which are crucial for maintaining the characteristics of leukemia cells. By studying the chromatin state and the effects of degrading NPM1c, the researchers aim to identify potential therapeutic targets that could lead to new treatment options for patients with this type of leukemia.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with acute myeloid leukemia who have NPM1c mutations.
Not a fit: Patients with other types of leukemia or those without NPM1c mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for patients with NPM1c mutant leukemia, improving treatment outcomes.
How similar studies have performed: Previous research has shown promising results in targeting similar molecular pathways in leukemia, suggesting potential for success in this approach.
Where this research is happening
BOSTON, UNITED STATES
- DANA-FARBER CANCER INST — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ARMSTRONG, SCOTT A — DANA-FARBER CANCER INST
- Study coordinator: ARMSTRONG, SCOTT A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.