Understanding how notochord cells contribute to spine and disc health
Official title: Regulation of notochord vacuole biogenesis: investigating its role in spine formation and IVD Biology
Funded at Duke University · NIH-11011459 · Data updated 2026-11-12
This study is looking at how certain cells in the spine help with its growth and health, which could be important for understanding conditions like scoliosis, and it’s for anyone interested in how our spines develop and change as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | January 16, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $530,090 |
| NIH project number | 5R01AR083346-02 |
| Project ID | NIH-11011459 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with congenital scoliosis or other spinal deformities, as well as those experiencing age-related spine issues.
✕Less likely to help
Patients with spinal conditions unrelated to notochord function or those without any spinal issues may not benefit from this research.
What this research studies
This research investigates the role of notochord vacuoles in the development of the spine and intervertebral discs (IVD). By examining how these specialized cells contribute to vertebral formation and their potential link to conditions like congenital scoliosis, the research aims to uncover the mechanisms behind spine health and degeneration. The study will utilize advanced techniques to analyze cell behavior and interactions in both animal models and human tissues, providing insights into how aging affects spinal health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for spinal disorders and improve understanding of age-related spine degeneration.
How similar studies have gone: Previous research has shown promising results in understanding notochord function in model organisms, suggesting potential for success in this area.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Bagnat, Michel — Duke University
- Study coordinator: Bagnat, Michel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.