Understanding how Notch2 influences B cell growth and antibody production
Official title: Notch2 Amplification of B Cell Division and Differentiation Fates
Funded at University of Pennsylvania · NIH-10900500 · Data updated 2026-11-12
This study is looking at how a specific pathway in our immune system helps B cells, which are important for making antibodies, grow and change into cells that can fight off viruses like SARS-CoV-2, with the hope of finding better ways to create vaccines.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $36,662 |
| NIH project number | 1F31AI179166-01A1 |
| Project ID | NIH-10900500 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been vaccinated against SARS-CoV-2 and are interested in understanding their immune response.
✕Less likely to help
Patients who are not vaccinated against SARS-CoV-2 or those with pre-existing conditions that severely impair their immune system may not benefit from this research.
What this research studies
This research investigates the role of the Notch2 pathway in the activation and differentiation of B cells, which are crucial for producing antibodies. By exploring how Notch2 influences B cell division and their readiness to become antibody-secreting plasma cells, the project aims to enhance our understanding of immune responses, particularly in relation to SARS-CoV-2. The study will utilize various laboratory techniques to analyze B cell behavior and responses to viral immunogens, potentially leading to improved vaccine strategies.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines that generate robust and long-lasting antibody responses against rapidly mutating viruses like SARS-CoV-2.
How similar studies have gone: Previous research has shown that understanding B cell activation pathways can lead to significant advancements in vaccine development, indicating that this approach has potential for success.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Londregan, Jennifer — University of Pennsylvania
- Study coordinator: Londregan, Jennifer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.