Understanding how Notch2 affects pancreatic neuroendocrine tumors
Official title: Characterizing the Role of NOTCH2 in Neuroendocrine Tumors
Funded at University of Alabama at Birmingham · NIH-10924006 · Data updated 2026-11-12
This study is looking at how a protein called Notch2 affects pancreatic neuroendocrine tumors, which are tricky cancers, to help doctors understand how these tumors grow and behave, with the goal of finding better ways to treat patients like you.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $51,750 |
| NIH project number | 5F31CA260945-03 |
| Project ID | NIH-10924006 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with pancreatic neuroendocrine tumors, particularly those with metastatic disease.
✕Less likely to help
Patients with non-neuroendocrine tumors or those without pancreatic cancer may not benefit from this research.
What this research studies
This research investigates the role of Notch2 in pancreatic neuroendocrine tumors (pNETs), which are a type of cancer that can be difficult to treat. The study aims to understand how Notch2 influences tumor growth, spread, and hormone production in these tumors. By analyzing tumor samples and using advanced techniques like CRISPR, researchers hope to identify how changes in Notch2 levels affect patient outcomes. This could lead to better predictions of disease progression and more effective treatment strategies for patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better prognostic tools for patients with pancreatic neuroendocrine tumors.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways in cancer treatment, indicating potential for success in this approach.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Herring, Brendon Robert — University of Alabama at Birmingham
- Study coordinator: Herring, Brendon Robert
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.