Understanding how Notch signaling works in cell communication during tissue development
DMS/NIGMS 1: Multiscale modeling of Notch signaling during long-range lateral inhibition
['FUNDING_R01'] · CLARKSON UNIVERSITY · NIH-10932403
This study is looking at how tiny projections on cells help them communicate with each other during the development of tissues and organs, which could be helpful for understanding conditions related to cell growth and signaling.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLARKSON UNIVERSITY (nih funded) |
| Locations | 1 site (POTSDAM, UNITED STATES) |
| Trial ID | NIH-10932403 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms of Notch signaling, which is crucial for the development of tissues and organs. It focuses on how signaling filopodia, which are tiny cellular projections, facilitate communication between distant cells. The project employs multi-scale modeling and biological experiments to explore how Notch activation occurs through these filopodia and how signals are transmitted to the cell body. By combining mathematical models with genetic approaches and live imaging, the research aims to create a comprehensive model of Notch signaling during the development of specific cell patterns.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to tissue development or signaling disorders.
Not a fit: Patients with fully developed tissues and no signaling disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of tissue development and potential therapeutic strategies for developmental disorders.
How similar studies have performed: While the approach of using multi-scale modeling in this context is innovative, similar studies have shown promise in understanding cellular communication and signaling.
Where this research is happening
POTSDAM, UNITED STATES
- CLARKSON UNIVERSITY — POTSDAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ASANTE-ASAMANI, EMMANUEL — CLARKSON UNIVERSITY
- Study coordinator: ASANTE-ASAMANI, EMMANUEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.