Understanding how Notch signaling works in cell communication during tissue development
Official title: DMS/NIGMS 1: Multiscale modeling of Notch signaling during long-range lateral inhibition
Funded at Clarkson University · NIH-10932403 · Data updated 2026-11-12
This study is looking at how tiny projections on cells help them communicate with each other during the development of tissues and organs, which could be helpful for understanding conditions related to cell growth and signaling.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clarkson University NIH-funded |
| Lab location | 1 site (Potsdam, United States) |
| Project start | September 25, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $196,114 |
| NIH project number | 5R01GM152810-02 |
| Project ID | NIH-10932403 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to tissue development or signaling disorders.
✕Less likely to help
Patients with fully developed tissues and no signaling disorders may not benefit from this research.
What this research studies
This research investigates the mechanisms of Notch signaling, which is crucial for the development of tissues and organs. It focuses on how signaling filopodia, which are tiny cellular projections, facilitate communication between distant cells. The project employs multi-scale modeling and biological experiments to explore how Notch activation occurs through these filopodia and how signals are transmitted to the cell body. By combining mathematical models with genetic approaches and live imaging, the research aims to create a comprehensive model of Notch signaling during the development of specific cell patterns.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of tissue development and potential therapeutic strategies for developmental disorders.
How similar studies have gone: While the approach of using multi-scale modeling in this context is innovative, similar studies have shown promise in understanding cellular communication and signaling.
Where this research is happening
-
Clarkson University
Potsdam, United States Active
Researchers
- Principal investigator: Asante-Asamani, Emmanuel — Clarkson University
- Study coordinator: Asante-Asamani, Emmanuel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.